After working for Reichlin, Reinhart and Santiago Calatrava in Switzerland he went to work in London in 1986 for the office of James Stirling, Michael Wilford and Associates, who became world famous with the Neue Staatsgalerie in Stuttgart. In 1990 Manuel Schupp opened in Stuttgart the German branch office of James Stirling, Michael Wilford and Associates and was appointed associate. Around the turn of the century Wilford Schupp Architects became the legal successor, and most currently has been renamed ORANGE BLU building solutions.

Among being on the managing board of the BDA (Association of German Architects), a member of the Stuttgart Urban Development Committee and a participant in the selection committee of the German National Academic Foundation, Manuel is also co-founder of the trade association “ena” (european network architecture). In 2013, together with Tankred Eckert, Peter Vorbeck and Jörg Lorenz, the building consultancy company fritzP. was established. Further adding to his professional spectrum, Manuel is a member of the supervisory board of the Technical University Stuttgart, where he teaches, gives lectures and is a juror in competitions.